During the American Revolution, Jefferson represented Virginia at the Second Continental Congress and served as the second governor of Virginia from 1779 to 1781. In 1785, Congress appointed Jefferson U.S. minister to France, where he served from 1785 to 1789. President Washington then appointed Jefferson the nation's first secretary of state, where he served from 1790 to 1793.

During this time, in the early 1790s, Jefferson and James Madison organized the Democratic-Republican Party to oppose the Federalist Party during the formation of the nation's First Party System. Jefferson and Federalist John Adams became both friends and political rivals. In the 1796 U.S. presidential election between the two, Jefferson came in second, which made him Adams' vice president. Four years later, in the 1800 presidential election, Jefferson again challenged Adams, and won the presidency. In 1804, Jefferson was reelected overwhelmingly to a second term.